How Sildenafil change the world
Sildenafil Makes History
Sildenafil was the first phosphodiesterase 5 (PDE5) inhibitor to be approved for the treatment of erectile dysfunction (ED). For men, ED is a prevalent sexual problem that becomes more common as they become older.
ED affects an estimated 30 million men in the United States and over 100 million men worldwide. According to a big survey conducted in the United States, almost half of all men aged 40 to 70 have some kind of ED. Diabetes makes men three times as likely to get ED.
Sildenafil’s Quick Success: FDA Approval
Sildenafil had the quickest initial sales increase of any prescription pharmaceutical at the time of its approval, reaching revenues of about $2 billion in 2008.
Pfizer used direct-to-consumer (DTC) advertising to raise awareness about Sildenafil and ED, prompting men to seek medical advice and a prescription from their doctors.
Since the release of Sildenafil and other PDE5 inhibitors, many men have felt less embarrassed about talking to their doctor about ED.
Why are men advised to take sildenafil?
Erectile dysfunction (impotence; inability to get or retain an erection) in men is treated with sildenafil (Viagra). In adults with pulmonary arterial hypertension, sildenafil is used to increase their ability to exercise (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness).
Sildenafil belongs to the class of drugs known as phosphodiesterase (PDE) inhibitors. Sildenafil improves blood flow to the private parts of men during sexual stimulation, which helps to treat erectile dysfunction. An erection may result from increased blood flow. Sildenafil cures PAH by allowing blood to flow freely by relaxing the blood vessels in the lungs.
If you’re taking sildenafil in the form of erectile dysfunction pills to treat erectile dysfunction, keep in mind that it won’t cure it or make you more sexually desirable. Sildenafil does not protect against pregnancy or sexually transmitted diseases such as the human immunodeficiency virus (HIV).
Erectile Dysfunction’s Effects (ED)
Erectile dysfunction (ED), can cause anxiety, damage to self-esteem and personal relationships, and even clinical depression.
According to a study published in the British Medical Journal, 62 percent of men reported a drop in self-esteem, 29 percent had a negative influence on a relationship, and 21 percent said their relationship had ended because of ED.
Many men’s feelings of masculinity are directly affected by their failure to perform well during sex.
What Causes Erectile Dysfunction (ED)?
Erectile dysfunction (ED) is caused by underlying health problems such as:
- High blood pressure
- High cholesterol
- Prolonged alcohol or drug misuse,
- Some drugs that can result in injury.
ED can be caused by any condition that restricts blood flow to veins over time, such as smoking or regular ageing.
ED can also be caused by medical illnesses like Parkinson’s disease or Peyronie’s disease (scar tissue build-up in the private parts of men).
Mental health disorders, such as sadness or stress, can also lead to a decrease of libido. Men who suffer from ED-related performance anxiety may encounter erection failures on a regular basis.
Just the Facts: How Does Sildenafil Work and Change the World?
Sildenafil, commonly known as viagra, increases blood flow to the private parts of men in response to sexual stimulation, resulting in an erection. Without sexual stimulus, Sildenafil does not produce an erection.
When a man feels excited, the muscles in his body relax, allowing more blood to flow through. With sexual stimulation, Sildenafil helps to raise the amounts of a chemical called cyclic guanosine monophosphate (or cGMP), which relaxes the tissues, increases blood flow, and causes an erection.
Erectile dysfunction (ED) is treated with Sildenafil and other PDE5 inhibitors including Cialis, Levitra, Stendra, and Staxyn, however, they do not immediately boost a man’s sexual drive.
Is There a Risk of Side Effects With Sildenafil?
The most common negative effects of PDE5 inhibitors, such as Sildenafil, are minor and temporary.
The following are possible side effects:
- Headache / Flushing
- Problems with vision (blurry vision, light sensitivity)
- Your vision has a blue-green tinge to it (usually a temporary side effect)
Notify your healthcare professional right away if you have abrupt hearing or vision loss. An erection that lasts more than four hours (priapism) is a rare occurrence, but if it happens, seek immediate medical attention.
Before taking Sildenafil, talk to your doctor about the possible adverse effects.
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